Table 2.
SNP |
rs3087243 G/A |
rs231775 G/A |
rs1045642 C/T |
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OR | 95%CI | P value | OR | 95%CI | P value | OR | 95%CI | P value | |
Allele model | |||||||||
Asians | 1.15 | 0.86-1.55 | 0.340 | 1.51 | 1.15-1.98 | 0.003 | 1.47 | 1.19-1.82 | < 0.001 |
Caucasians | 1.56 | 1.06-2.31 | 0.026 | 1.72 | 1.24-2.39 | 0.001 | 1.34 | 1.13-1.59 | 0.001 |
Africas | - | - | - | 1.56 | 0.97-2.49 | 0.066 | - | - | - |
Overall | 1.37 | 1.02-1.82 | 0.035 | 1.58 | 1.31-1.92 | < 0.001 | 1.39 | 1.21-1.59 | < 0.001 |
Dominant model | |||||||||
Asians | 1.38 | 0.96-1.97 | 0.079 | 1.90 | 1.31-2.75 | 0.001 | 1.72 | 1.26-2.36 | 0.001 |
Caucasians | 1.69 | 1.29-2.19 | < 0.001 | 1.89 | 1.21-2.95 | 0.005 | 1.35 | 1.00-1.83 | 0.048 |
Africas | - | - | - | 1.43 | 0.76-2.68 | 0.263 | - | - | - |
Overall | 1.57 | 1.27-1.94 | < 0.001 | 1.81 | 1.39-2.34 | < 0.001 | 1.52 | 1.22-1.89 | < 0.001 |
Homozygous model | |||||||||
Overall | 2.41 | 1.67-3.48 | < 0.001 | 2.21 | 1.45-3.37 | < 0.001 | 1.92 | 1.44-2.56 | < 0.001 |
Heterozygous model | |||||||||
Overall | 0.62 | 0.44-0.89 | 0.008 | 0.76 | 0.50-1.15 | 0.190 | 0.67 | 0.53-0.86 | 0.001 |
Recessive model | |||||||||
Overall | 1.98 | 1.42-2.76 | < 0.001 | 1.73 | 1.16-2.57 | 0.007 | 1.62 | 1.29-2.05 | < 0.001 |
OR: Odds ratio.