Table 1.
Demographic characteristics of participants and best FEV1% predicted at age 6–7 years
| Risk Factor | Baseline, n (%)* |
Best FEV1% predicted at age 6–7, Mean (SD) |
P Value | |||
|---|---|---|---|---|---|---|
| Participants with Risk Factor | Participants without Risk Factor | Participants with Risk Factor | Participants without Risk Factor | Mean Difference (95% Confidence Interval) | ||
| Age enrolled, 2 to <4 yr | 237 (49.0) | 247 (51.0) | 107.9 (16.0) | 109.9 (14.6) | −1.9 (–4.7, 0.8) | 0.17 |
| Female | 241 (49.8) | 243 (50.2) | 108.1 (15.6) | 109.7 (15.0) | −1.5 (–4.2, 1.2) | 0.28 |
| F508del homozygous† | 254 (52.5) | 219 (45.2) | 110.0 (15.0) | 107.9 (15.6) | 2.1 (–0.7, 4.9) | 0.14 |
| Diagnosed by screening‡ | 168 (34.7) | 300 (62.0) | 111.1 (15.0) | 107.8 (15.6) | 3.2 (0.4, 6.1) | 0.03 |
| Meconium ileus‡ | 127 (26.2) | 341 (70.4) | 109.0 (14.0) | 109.0 (15.9) | −0.0 (–3.0, 2.9) | 0.98 |
| Mother’s education high school or less§ | 133 (27.5) | 345 (71.3) | 105.4 (15.3) | 110.2 (15.1) | −4.8 (–7.9, –1.7) | 0.002 |
| Household income <$40,000§ | 150 (31.0) | 284 (58.7) | 107.1 (16.3) | 109.8 (14.7) | −2.7 (–5.8, 0.4) | 0.09 |
| Medicaid recipient§ | 211 (43.6) | 267 (55.2) | 107.2 (16.2) | 110.1 (14.5) | −2.9 (–5.7, –0.1) | 0.05 |
| Weight < 10th percentile|| | 70 (14.5) | 414 (85.5) | 104.3 (15.5) | 109.7 (15.1) | −5.4 (–9.3, –1.5) | 0.007 |
| Height < 10th percentile|| | 85 (17.6) | 399 (82.4) | 105.2 (17.0) | 109.7 (14.8) | −4.5 (–8.4, –0.6) | 0.02 |
| Body mass index < 10th percentile|| | 8 (3.4) | 229 (96.6) | 105.1 (17.1) | 108.0 (16.0) | −2.9 (–14.3, 8.5) | 0.62 |
All percentages reflect a denominator of 484 participants with the exception of body mass index (which was assessed only in 237 children ≥ 2 yr of age at enrollment). Mean differences and P values reflect simple linear regression models.
Genotype data were missing for 11 participants.
Diagnosis by screening includes prenatal and newborn screening. Data related to diagnosis by screening and meconium ileus were missing for 16 participants.
Education and income reflect family survey data reported during the year of enrollment. Medicaid status reflects data reported in the Cystic Fibrosis Foundation National Patient Registry during the year of enrollment. Items with missing data included education (n = 6), income (n = 50), and Medicaid status (n = 6).
Weight, height, and body mass index percentiles reflect the mean of best quarterly values during the year of enrollment.