Table 1.

Prostasome-driven thrombin generation

	NP	NP + Inf-4	FXII def.	FXI def.	NP + ASIS	NP + Inf-4 + ASIS
Lag time (min)	10.7 ± 1.0	22.0 ± 3.7*	16.0 ± 2.5†	21.0 ± 2.0*	20.6 ± 1.9‡	NA
Time to peak (min)	15.2 ± 1.1	30.1 ± 5.0‡	25.3 ± 2.7‡	27.9 ± 2.1‡	33.3 ± 4.1‡	NA
Peak thrombin (nM)	191.1 ± 16.0	109.4 ± 31.3*	94.3 ± 20.1‡	41.6 ± 14.5‡	51.9 ± 12.8‡	NA
ETP (nM⋅min)	1622 ± 59	998 ± 267†	1098 ± 186†	568 ± 176‡	686 ± 157‡	NA

Comparison of PC3 prostasome-induced thrombin formation in platelet free normal plasma (NP), NP supplemented with rHA-Infestin-4 (Inf-4; 500 µg/mL), ASIS (30 nM), or a combination of ASIS and Inf-4 (30 nM and 500 µg/mL) and plasma deficient in FXII (FXII def.) or FXI (FXI def.) as done in Figure 2G-H. Values are expressed as mean ± SEM, n = 3 to 11. ETP, endogenous thrombin potential; NA, below the detection limit.

^*P < .01 vs buffer-treated NP, ANOVA.

^†P < .05 vs buffer-treated NP, ANOVA.

^‡P < .001 vs buffer-treated NP, ANOVA.