Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	Adults with advanced illness, chronic non-malignant pain, or having an orthopaedic procedure, based in primary, secondary, and tertiary care 4 RCTs in this analysis	Total number of adverse events with methylnaltrexone with placebo Absolute results not reported	RR 1.24 95% CI 0.98 to 1.57		Not significant
Systematic review	Adults with advanced illness, chronic non-malignant pain, or having an orthopaedic procedure, based in primary, secondary, and tertiary care 4 RCTs in this analysis	Diarrhoea with methylnaltrexone with placebo Absolute results not reported	RR 1.94 95% CI 1.13 to 3.30 NNH 30 95% CI 18 to 111	Small effect size	placebo