Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	Adults with chronic non-malignant pain, stable opioid dose, based in secondary and tertiary care 4 RCTs in this analysis	Total number of adverse events with alvimopan with placebo Absolute results not reported	RR 1.07 95% CI 0.98 to 1.17		Not significant
Systematic review	Adults with chronic non-malignant pain, stable opioid dose, based in secondary and tertiary care 4 RCTs in this analysis	Diarrhoea with alvimopan with placebo Absolute results not reported	RR 1.56 95% CI 1.01 to 2.40 NNH 28 95% CI 16 to 100	Small effect size	placebo
Systematic review	Adults with chronic non-malignant pain, stable opioid dose, based in secondary and tertiary care 3 RCTs in this analysis	Headache with alvimopan with placebo Absolute results not reported	RR 1.52 95% CI 1.02 to 2.27 NNH 33 95% CI 16 to 200	Small effect size	placebo