. Author manuscript; available in PMC: 2016 Oct 15.

Published in final edited form as: Int J Cancer. 2015 May 26;137(8):1901–1909. doi: 10.1002/ijc.29570

Table 3.

Effect of haplotypes bearing the two AFAP1L2 SNPs on the risk of melanoma by stratifying on genotypes at TERF1 rs3863241 in pooled MELARISK and MDACC datasets

AFAP1L2 haplotypes			Genotypes of rs3863241 (TERF1)³
AFAP1L2 haplotypes			TT (844 cases/1,073 controls)		CT (1,404 cases/1,839 controls)		CC (607 cases/737 controls)

rs649785¹	rs597371¹	Freq²	OR (95% CI)⁴	p ⁵	OR (95% CI)⁴	p ⁵	OR (95% CI)⁴	p ⁵
G	A	0.49	.	.	.	.	.	.

C	G	0.38	1.31 (1.13-1.52)	2.9×10⁻⁴	1.05 (0.93-1.17)	0.44	0.71 (0.59-0.85)	2.7×10⁻⁴

C	A	0.10	1.05 (0.82-1.36)	0.70	0.97 (0.80-1.17)	0.73	0.78 (0.58-1.04)	0.09

G	G	0.03	0.91 (0.61-1.36)	0.65	0.73 (0.53-1.01)	0.06	1.19 (0.72-1.98)	0.49

C is rs649785 minor allele; G is rs597371 minor allele

Haplotypes frequencies estimated in controls of the pooled sample. This frequency was similar in each stratum defined by TERF1 rs3863241 genotypes

Haplotype analysis was conducted in each stratum of subjects according to their genotype at rs3863241 (TERF1)

⁴

OR (95% CI) is the odds-ratio (95% confidence interval) for each haplotype with respect to the reference haplotype (GA)

⁵

p-value associated with Wald-test statistic