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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biomaterials. 2015 Jul 21;67:354–364. doi: 10.1016/j.biomaterials.2015.07.039

Figure 5.

Figure 5

(A) Adhered platelets on VEC only, VIC only, and HEAVM scaffolds relative to the number of adhered platelets on blank acellular scaffolds. HEAVM co-cultures had significantly less platelet adhesion than VIC only scaffolds, significantly more adhered platelets than VEC only cultures, but not significantly different from blank gel. VIC only was significantly higher than all other cases. n = 6–8. Bars that are not connected be the same letter significantly different. p < 0.05. (B) VEC only scaffolds stained for DiI-AcLDL and had minimal visible platelet adhesion across the hydrogel surface. (C). Large platelet clumps adhered to regions where VICs were present on the surface on VIC only scaffolds. (D) Platelets adhered on acellular, blank HEAVM scaffolds. (E) Most HEAVM co-culture scaffolds stained for DiI-AcLDL on the surface coated monolayer and had minimal platelet adhesion. (F) Blank regions and (G) cells negative to DiI-AcLDL uptake on HEAVM co-cultures promoted platelet clump adhesion. Scale bars = 50 μm.