Table 6. Cytotoxicities of Resveratrol Oligomers Against Various Cancer Cell Lines.
cell lines; refs | most active compd | (EC50, μM)a |
---|---|---|
Cervical (Adeno)carcinoma | ||
HeLa; (87, 247−251) | pauciflorol B | 2.8 |
HSG; (252) | sophorastilbene A | 108.0 |
KB; (66, 87, 141, 251, 253, 145) | peracetyl ampelopsin A | 0.8 |
Ovarian (Adeno)carcinoma | ||
1A9; (253) | peracetyl ampelopsin A | 1.0 |
SK-OV-3; (254) | cis-vitisin A | 0.17 |
Breast (Adeno)carcinoma | ||
MCF-7; (247−250, 253, 255−258) | peracetyl ampelopsin A | 2.8 |
MDA-MB-231; (250, 257, 259) | hopeachinol E | 14.3 |
BJMC-3879; (286) | vaticanol C | 8.0 |
BC-1; (141) | (−)-vatdiospyroidol | 4.2 |
Leukemia | ||
P-388; (260, 289) | (−)-hopeaphenol | 5.2 |
EHEB; (261) | N/A | N/A |
WSU-CLL and ESKOL; (261) | ε-viniferin | 6.7 |
Jurkat; (262) | miyabenol C | 29.4 |
HL-60; (247, 252, 258, 289, 263−267) | vaticanol C | 3.0 |
K-562; (262, 265) | miyabenol C | 18.7 |
Myeloma | ||
U-266; (262) | miyabenol C | 12.1 |
RPMI-8226; (262) | miyabenol C | 20.8 |
Lymphoma | ||
U-937; (262, 265, 268) | heyneanol A | 6.6 |
Colon (Adeno)carcinoma | ||
HCT-116; (257, 259, 269, 270) | α-viniferin | 6.6 |
HT-29; (248, 249, 257, 269) | α-viniferin | 32.6 |
Caco-2; (269) | α-viniferin | 16.1 |
Col-2; (141) | (−)-vatdiospyroidol | 2.1 |
HCT-8; (253) | peracetyl ampelopsin | 5.7 |
SW-480; (265, 270, 285, 271) | A vaticanol C | 3.2 |
DLD-1; (265, 285) | vaticanol C | N/A |
COLO-201; (265, 285) | vaticanol C | N/A |
Lung (Adeno)carcinoma | ||
A-549; (250, 253, 254, 258, 272, 273) | cis-vitisin A | 0.93 |
NCI-H446; (269, 272, 273) | α-viniferin | 16.1 |
NCI-H460; (272) | kobophenol A | 200 |
NCI-H1299; (250) | vaticanol A | 19.7 |
SPC-A-1; (272) | ||
Liver Carcinoma | ||
Hep-G2; (248, 249, 258, 259, 274) | hopeachinol J | 12.4 |
SMMC-7721; (259) | hopeachinol F | 10.4 |
Clear Cell Renal Carcinoma | ||
Caki-1; (253) | peracetyl ampelopsin A | 5.5 |
Prostate (Adeno)carcinoma | ||
LNCaP; (265) | vaticanol C | N/A |
PC-3; (265) | α-viniferin | N/A |
Neuroblastoma | ||
SH-SY5Y; (265, 275) | vaticanol C | N/A |
C6; (249) | gnetin H | 18.7 |
Sarcoma | ||
S-180; (276) | extract-Vat. indica | 29.5 |
SaOS-2; (253) | peracetyl ε-viniferin | 11.3 |
Oral Squamous Carcinoma | ||
HSC-2; (252) | sophorastilbene A | 27.0 |
HSC-3; (252) | (+)-α-viniferin | 60.0 |
Malignant Melanoma | ||
SK-MEL-2; (253, 254) | vitisin B | 4.9 |
All values reported as (μg/mL) have been converted to EC50 (μM) for the sake of comparison.