Table 2.

Diet induced obesity and alterations in mouse brain homeostasis

Diet	Duration	Mouse Strain	End Point & Results	Ref.
60%-HFD, 10%-CD	16 weeks	C57BL/6	increased reactive oxygen species (ROS); decreased cognition	[43]
60%-HFD, 5%-CD	16 weeks	C57BL/6	increased IR, ROS; no AD histopathology, no increase in Aβ or phospho-tau, no impairments in IGF signaling or acetylcholine homeostasis	[33]
10% sucrose in water	25 weeks	B6C3-Tg(APPswe, PSEN1dE9)85Dbo/J	Metabolic dysfunction, memory impairment, increased apoE and aggregation of Aβ in the brain	[34]
40%-WD, 10%-CD	4 weeks	APPswe/PS1M146V; PS1M146V; C57BL/6	increased cerebral ROS, alterations in brain Aβ	[36]
60%-HFD	16 weeks	C57BL/6	impairment of fear-conditioning test	[53]
60%-HFD, 10%-CD	20 weeks	APPSwe/Ind	metabolic dysfunction; decreased cognition	[54]
21.2%-HFD, 5.5%-CD	22 weeks	C57BL/6	increased pro-inflammatory factors and APP expression in brains and fat tissues	[55]
55% -HFD	8 weeks	WT, PSEN1, APP/PSEN1	AD increases body weight gain, glucose intolerance and insulin resistance induced by HFD in mice	[56]
60%-HFD	20 weeks	C57BL/6J, MC4R−/−, Tie2-GFP	enhanced GFAP-immunoreactivity in the medial preoptic, paraventricular and dorsomedial nuclei of the hypothalamus.	[57]
60%-HFD	22 weeks	C57BL/6	impaired hippocampus-dependent spatial memory, alteration in the expression of corresponding genes	[58]
58%-HFD, 10.5%-CD	12 weeks	C57BL/6	promotion of negative emotional states and depressive-like symptomology	[59]
45%-HFD, 10%-CD	14 weeks	C57BL/6	HFD selectively protects against the effects of chronic social stress in the mouse	[60]