Figure 4.

Critical roles of Lhx6 and -8 in epithelium–mesenchyme crosstalk. Epithelium-derived FGF8 and TGF-β3 bind to their receptors in the underlying mesenchyme, resulting in the upregulation of Lhx6 and -8. Lhx8, together with Lhx6, is involved in odontogenesis through regulating Msx1, Msx2, Bmp4, Gsc, and others.