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A glucose-sensitive miRNA network. Glucose (brown circle) affects the expression levels of (at least) 11 different miRNAs from the 14q32 cluster (half ovals) that in turn target the genes Ptprn, Ptprn2, and Gad2, which encode, respectively, 3 of the major T1D autoantigens: IA-2, IA-2β, and GAD65. Arrows: miRNA targets. Some of these miRNAs target more than 1 gene (2 or 3 arrows originating from the same miRNA). Dark arrows: confirmed targets.
