Attrition bias/Intention‐to‐treat An intention‐to‐treat analysis is one in which all the participants in a trial are analysed according to the intervention to which they were allocated, whether they received it or not.
Loss to follow up?	Reported reported as none Uncertain/not reported not applicable
ITT Analysis?	Reported not reported no Uncertain not applicable
PP Analysis?	Reported not reported Uncertain not applicable
Were withdrawals described?	Yes No Not clear
How were lost participants/withdraw accounted for:	Last observation carried forward Information collected at end of study Uncertain/not reported Excluded
Comments
Bias likely	Yes/No/Unclear
Selective Reporting Did the study authors report the primary outcomes or is the reported significant outcome a secondary outcome, while the primary outcome of the study was negative.
Primary outcome stated	Prior to study begin, e.g. in protocol After completion of study, e.g. in publication
Outcome was the primary outcome of the reported study	Yes No Unclear
Conflict of Interest and Sponsors Is there a statement on potential conflict of interests or sponsors and did these have an undue influence on the analysis of the data
Conflict of interest	Statement on COI: Yes No
	No indication of relevant COI Unclear Possible conflict of interest apparent
Sponsors	No report on sponsors Unclear information on sponsor Sponsor reported and detailed information
	Possible undue influence apparent Unclear Undue sponsor influence unlikely