Table 3.
Microbiologic and Radiologic Findings in Patients With Histoplasma-Associated HLH
| Case Number | Bone Marrow With Yeast | Histoplasma on Peripheral Smear | Bone Marrow With Hemophagocytosis | Histoplasma Antibodya (<1:8) | Urine Histoplasma Ag (<2.0 EIA) | Sites Growing Histoplasma | CXR Findings |
|---|---|---|---|---|---|---|---|
| 1 | Yes | Yes | Yes | N/A | N/A | Blood, bone marrow, | BI, B effusions, CM |
| 2 | Yes | Yes | Yes | Positive | Positive | None | BI, LAD |
| 3 | No | No | Yes | N/A | >13 | Blood | Hemothorax, right pneumothorax |
| 4 | No | No | Yes | Positive | Positive | None | BI, L effusion |
| 5 | Yes | Yes | Yes | N/A | >13 | Blood, bone marrow | Clear |
| 6 | Yes | No | Yes | N/A | >13 | Bone marrow, skin | CM |
| 7 | Yes | No | Yes | N/A | 11 | Sputum, blood | Edema, BI, effusions |
| 8 | Yes | No | Yes | Positive | >19 | Bone marrow | Miliary nodules, effusions, LAD |
| 9 | Yes | No | Yes | N/A | >19 | Blood, bone marrow | Miliary nodules |
| 10 | Yes | No | Yes | Positive | N/A | Respiratory blood, bone marrow | CM, BI, nodules, L effusion |
| 11 | No | Yes | Not done | Negative | 4.9 | Respiratory, blood, gastric tissue | BI, nodules |
Abbreviations: Ag, antigen; B, bilateral; BI, bilateral infiltrates; CM, cardiomegaly; EIA, enzyme immunoassay; HLH, hemophagocytic lymphohistiocytosis; L, Left; LAD, lymphadenopathy; N/A, not applicable (not reported).
a Complement fixation titer, ARUP laboratories.