Table 5.

Treatment and outcomes of Histoplasma-associated hemophagocytic lymphohistiocytosis

Case Number	Antifungal drug used	Liposomal amphotericin B duration (days)	Oral antifungal duration (days)	Immuno suppressive treatment	HAART at time of diagnosis	Immuno suppressive duration	HAART started during admission	Outcome at 30 days	Survival from admission (days)
1	Liposomal amphotericin B	Unknown	0 days	None	Yes	None	No	Died	16
2	Liposomal amphotericin B; itraconazole	14	Unknown	None	Yes	None	Yes	Alive	2168
3	Liposomal amphotericin B; fluconazole	21	>1 year	Prednisone 20 mg PO daily	No	Unknown	No	Died	221
4	Itraconazole	0	Unknown	None	N/A	None	N/A	Alive	44
5	Unknown	Unknown	Unknown	Unknown	Yes	Unknown	Unknown	Alive	3560
6	Liposomal amphotericin B; voriconazole	Unknown	Unknown	Prednisolone 10 mg po BID, Tacrolimus 1.5 mg PO daily	N/A	5 months	N/A	Alive	2849
7	Liposomal amphotericin B; itraconazole	16	12 weeks	None	No	None	No	Alive	86
8	Liposomal amphotericin B; itraconazole	5	0 days	IVIG × 1; prednisone 40 BID	No	9 days	No	Died	9
9	Liposomal amphotericin B; itraconazole	3	Unknown	IVIG 1gm × 1	No	1 day	No	Died	9
10	Liposomal amphotericin B; itraconazole	18	>1 year	None	Yes	None	No	Alive	408
11	Liposomal amphotericin B	11	0 days	Prednisone 40 mg PO BID; solumedrol 60 mg IV q6hrs	No	11 days	Yes	Died	13

Abbreviations: HAART, Highly active antiretroviral therapy; IVIG, intravenous immunoglobulin.