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. 2015 Mar 18;50(3):214–220. doi: 10.1310/hpj5003-214

Table 3. Drugs incompatible with cloxacillin sodiuma (100 mg/mL) in simulated Y-site administration (did not comply with USP specifications for particulate matter in injections).

Drug Concentration (mg/mL) Manufacturer Lot Incompatibility
1 Amikacin sulfate 250 Sandoz CB8036 >30 x 25 µm particles/mL at T=0
2 Azithromycin monohydrate 100 Sterimax 7005545 Precipitation at T=0
3 Chlorpromazine hydrocholoride 25 Sandoz AY5529 Precipitation at T=0
4 Ciprofloxacin lactate 2 Omega A020282 >30 x 25 µm particles/mL at T=0
5 Diazepam 5 Sandoz BB9997, 159114, CA4470 >30 x 25 µm particles/mL at T=0
6 Diphenhydramine
hydrochloride		 50 PPC 6004001, 6003080 Precipitation at T=0
7 Dobutamine hydrochloride 12.5 Hospira 12-088-DK Precipitation at T=0
8 Droperidol 2.5 Sandoz BT 9146 Precipitation at T=0
9 Erythromycin lactobionate 50 Amdipharm 88-409-TB-23 Precipitation at T=0
10 Gentamicin sulfate 40 Sandoz CG2537 Precipitation at T=0
11 Hydralazine hydrochloride 20 Sterimax 00501B10 Yellow opaque at T=4h
12 Labetalol hydrochloride 5 Sandoz CN4355 Precipitation at T=0
13 Lorazepam 4 Sandoz CA7061 >30 x 25 µm particles/mL at T=4h
14 Midazolam 5 PPC 6003319,
6003849		 Precipitation at T=0
15 Morphine sulfate 50 Sandoz BX6159 Precipitation at T=0
16 Nitroglycerin 5 Omega 1F690 >30 x 25 µm particles/mL at T=4h
17 Phenytoin sodium 50 Sandoz CH9389, BK8196, CG2519, BT9159 Precipitation at T=1h
18 Piperacillin sodium 300 Hospira 1P301MC1 >30 x 25 µm particles/mL at T=0
19 Potassium phosphate 3mmol/mL PPC 6103592 >30 x 25 µm particles/mL at T=4h
20 Promethazine hydrochloride 25 Sandoz BP2439 Precipitation at T=0
21 Rocuronium bromide 10 Merck 179835 Precipitation at T=0
22 Ticarcillin/clavulanic acid 200/6.7 GSK 553181 >30 x 25 µm particles/mL at T=0
23 Tobramycin sulfate 40 Sandoz CB9754 Precipitation at T=0
24 Trimethoprim/Sulfamethoxazole 16/80 Aspen Triton 1L255 >30 x 25 µm particles/mL at T=0 & 4h
25 Vancomycin hydrochloride 50 PPC 6103664 Precipitation at T=0

Note: T=0 = initial time; T=1h = time at 1 hour; T=4h = time at 4 hours.

a

Sterimax, lot 1CL1218CA.