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. 2015 Sep 4;9:5099–5113. doi: 10.2147/DDDT.S90201

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© 2015 Du et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Knockdown of LXRα abrogated the anthocyanins-induced NFκB gene expression in HK-2 cells.

Notes: Cells were transfected with pLV-NR1H3-shRNA plasmid or scrambled control shRNA plasmid for 24 h and then treated with HG (30 mM) in the presence or absence of C3G and Cy (50 µM) for 48 h, respectively. (A) The expression levels of NFκB cytoplasm protein and nuclear protein were detected by Western blot. (B) Nuclear translocation of NFκB p65 was investigated by immunocytochemistry staining. The values presented are the mean ± SD of three independent experiments. *P<0.01 versus control group, ^#P<0.01 versus HG group. ^$P<0.01 versus HG + C3G group, ^P<0.01 versus HG + Cy group.

Abbreviations: C3G, cyanidin-3-O-β-glucoside chloride; Cy, cyanidin chloride; h, hour/s; HG, high-glucose; NG, normal glucose.