Table 2.
Unadjusted linear regression correlations between PAF species and depressive symptoms in CAD patients (n=26)
| PAF species (m/z peak and identity) | HAM-D total score
|
||
|---|---|---|---|
| Pearson correlation (r) | R2 | P-value | |
| [468.3a] Pc(O-12:0/2:0) | 0.49 | 0.24 | 0.01 |
| [482.4a] Pc(O-13:0/2:0) | 0.38 | 0.15 | 0.05 |
| [496.3a] Pc(O-14:0/2:0) | 0.15 | 0.02 | 0.48 |
| [494.3a] Pc(O-14:1/2:0) | 0.43 | 0.18 | 0.03 |
| [510.4d] Pc(O-15:0/2:0) | 0.08 | 0.01 | 0.71 |
| [524.4a] Pc(O-16:0/2:0) | 0.14 | 0.02 | 0.51 |
| [522.4a] Pc(O-16:1/2:0) | 0.17 | 0.03 | 0.40 |
| [520.3a] Pc(O-16:2/2:0) | 0.09 | 0.01 | 0.66 |
| [532.3a] Pc(O-17:3/2:0) | 0.44 | 0.19 | 0.04 |
| [552.4e] Pc(O-18:0/2:0) | 0.22 | 0.05 | 0.28 |
| [550.4a] Pc(O-18:1/2:0) | 0.14 | 0.02 | 0.51 |
| [548.4b] Pc(O-18:2/2:0) | −0.19 | 0.04 | 0.35 |
| [546.3a] Pc(O-18:3/2:0) | 0.50 | 0.25 | 0.01 |
| [544.4a] Pc(O-18:4/2:0) | 0.15 | 0.02 | 0.47 |
| [542.3b] Pc(O-18:5/2:0) | −0.20 | 0.04 | 0.33 |
| [540.4a] Pc(O-18:6/2:0) | 0.01 | 0.00 | 0.96 |
| [556.4d] Pc(O-19:5/2:0) | −0.16 | 0.03 | 0.46 |
| [572.3b] Pc(O-20:4/2:0) | 0.14 | 0.02 | 0.50 |
| [570.3e] Pc(O-20:5/2:0) | 0.18 | 0.03 | 0.38 |
| [568.4a] Pc(O-20:6/2:0) | 0.07 | 0.01 | 0.72 |
Notes: Nomenclature adheres to the recent reorganization of ontologies for lipid classes and the curated list of lipid species identified by the CIHR Training Program in Neurodegenerative Lipidomics (CTPNL) teams.25,36 PC(O-20:4/2:0), for example, defines a lipid species with a phosphocholine (PC) polar head group, an ether linkage at the sn-1 position (O-) with a chain of 20 carbons, and 2 carbons linked by an ester linkage at the sn-2 position, of which the sn-1 chain has four degrees of unsaturation (indicated as: 4) whereas the sn-2 chain is characterized by fully saturated acetyl group (referred to by: 0). The number preceding species name in brackets refers to m/z of [M + H]+ ion. Letters distinguish species isobaric with other lipid second messengers in the curated CTPNL phospholipid list. Trends are highlighted in pink; significant associations are highlighted in yellow. P-value significance at P≤0.05.
Abbreviations: CAD, coronary artery disease; PAF, platelet activating factor; HAM-D, 17-item Hamilton Depression Rating Scale; PC, phosphocholine; CIHR, Canadian Institutes of Health Research.