Table 2. Selected down-regulated proteins in P. brasiliensis Pb18 yeast cells during macrophage infection.

Accession number 1	Protein description	Score 2	Fold change 3
Glycolysis
PADG_01896	Phosphoglycerate kinase	10933.7	0.20
PADG_03813	Hexokinase	1005.71	*
PADG_00192	6-phosphofructokinase	1158.94	*
PADG_00668	Fructose bisphosphate aldolase	19990.67	0.37
Protein synthesis
PADG_04057	Translation initiation factor eIF3	4000.27	*
PADG_00932	Translation initiation factor eIF3	478.38	*
PADG_01891	Translation initiation factor RLI1	656.19	*
PADG_06110	Translation factor SUI1	3845.67	*
PADG_00692	Elongation factor 1 alpha	25477.84	0.23
PADG_02759	Ribosome recycling factor domain-containing protein	1902.46	*
PADG_02752	116 kDa U5 small nuclear ribonucleoprotein component	110.37	0.53
PADG_04730	Nascent polypeptide associated complex subunit alpha	1887.05	*
PADG_02896	Elongation factor 1 beta	27699.38	0.36
PADG_06265	Elongation factor 1 gamma 1	21636.54	0.41
PADG_08125	Elongation factor 2	8384.21	0.45
PADG_03431	Putative tRNA-binding protein	533.64	*
PADG_03440	Prolyl tRNA synthetase	454.75	*
PADG_01558	Histidyl tRNA synthetase	1005.73	*
PADG_02484	Valyl tRNA synthetase	844.82	*
PADG_03689	Tyrosyl tRNA synthetase	1451.04	*
PADG_05848	Glycyl tRNA synthetase	600.14	*
PADG_05897	Seryl tRNA synthetase	2707.68	*
PADG_08472	Lysyl tRNA synthetase	857.74	*
PADG_04962	Aspartyl tRNA synthetase	2972.06	0.54
PADG_00785	Ribosomal protein S15	1042.95	*
PADG_01503	37S ribosomal protein Rsm24	553.96	*
PADG_04866	40S ribosomal protein S10 A	3053.9	*
PADG_02445	40S ribosomal protein S15	10623.49	0.39
PADG_06502	40S ribosomal protein S20	7199.8	0.48
PADG_06599	40S ribosomal protein S25	539.48	*
PADG_08605	40S ribosomal protein S28	4991.9	*
PADG_04848	60S ribosomal protein L8 B	14038.4	0.63
PADG_02828	60S ribosomal protein L10a	1216.32	0.59
PADG_07803	60S ribosomal protein L12	9790.37	0.63
PADG_06726	60S ribosomal protein L17	2919.98	0.66
PADG_01026	60S ribosomal protein L43	7369.92	0.66

¹ Accession number obtained in the Paracoccidioides database available at http://www.broadinstitute.org/annotation/genome/paracoccidioides_brasiliensis/MultiHome.html.

² PLGS score is the result of different mathematical models for peptide and fragment assign prediction.

³ Fold-change values were obtained by dividing the values of protein abundance (in fmol) from P. brasiliensis yeast cells during macrophage infection by the abundance in the control. Proteins with a minimum fold-change of 50% were considered to be regulated.

* Proteins detected in P. brasiliensis Pb18 only under the control condition.