Fig 5. PD-1 blockade restores the proliferation of exhausted T cell resulted by lymphoma cells.

T cells were labeled with CSFE and stimulated with OCI-Ly-10 cells, LCL cells and SU-DHL-4 cells, respectively. Percentages indicate the fraction of cells in the non-dividing peak. Shown are CD3-positive-gated histograms from a representative experiment (n = 4). Tumor cells inhibite T cell proliferation as observed by CSFE staining, and through PD-1 blockade T cell proliferation restored.