Fig 1. α-synuclein-induced locomotion defects and shortened lifespan.

(A) Expression of A30P α-synuclein specifically in the nervous system shortened lifespan. Survival curves were compared using the log-rank test (P<0.01 between elav>w ¹¹¹⁸ and elav>α-synuclein A30P flies). (B) There is no difference for climbing ability for flies expressing A30P α-synuclein and control genotype at day 10. In contrast, PD flies showed significant age dependent locomotive impairments at days 30 and 40 (*P<0.05). Control flies: elav>w ¹¹¹⁸; PD flies: elav>α-synuclein (A30P).