Table 4. Cox proportional hazards models for mortality prediction according to the biomarker levels and the severity scores.
Variable | Univariate Cox model | Multivariable Cox model | ||
---|---|---|---|---|
HR(95%CI) | p-value | HR(95%CI) | p-value | |
CIRP0.1 | 1.05(1.01–1.08) | 0.009 | 1.05(1.01–1.09) | 0.012 |
APACHE II score | 1.05(1.01–1.09) | 0.007 | 1.05(0.99–1.11) | 0.112 |
SOFA score | 1.10(1.01–1.21) | 0.028 | 0.98(0.84–1.13) | 0.742 |
Lactate | 1.18(1.05–1.34) | 0.008 | 1.26(1.10–1.45) | 0.001 |
Serum creatinine | 1.00(1.00–1.00) | 0.940 | 1.00(1.00–1.00) c | 0.820 |
PCT | 1.00(0.99–1.02) | 0.426 | 1.00(0.98–1.02) | 0.821 |
WBC | 1.01(0.96–1.07) | 0.594 | 1.024(0.98–1.08) | 0.339 |
N% | 0.97(0.93–1.00) | 0.061 | 0.96(0.92–1.00) | 0.037 |
CIRP = cold-inducible RNA-binding protein, APACHE II = Acute Physiology and Chronic Health Evaluation II, SOFA = Sepsis-related Organ Failure Assessment, PCT = procalcitonin, WBC = white blood cell, N% = neutrophil ratio.
CIRP0.1 = CIRP level/10.
HR = hazard ratio.
A p-value < 0.05 was considered to be statistically significant.
c = 0.998–1.002