Table 4. Cox proportional hazards models for mortality prediction according to the biomarker levels and the severity scores.

Variable	Univariate Cox model		Multivariable Cox model
	HR(95%CI)	p-value	HR(95%CI)	p-value
CIRP0.1	1.05(1.01–1.08)	0.009	1.05(1.01–1.09)	0.012
APACHE II score	1.05(1.01–1.09)	0.007	1.05(0.99–1.11)	0.112
SOFA score	1.10(1.01–1.21)	0.028	0.98(0.84–1.13)	0.742
Lactate	1.18(1.05–1.34)	0.008	1.26(1.10–1.45)	0.001
Serum creatinine	1.00(1.00–1.00)	0.940	1.00(1.00–1.00) c	0.820
PCT	1.00(0.99–1.02)	0.426	1.00(0.98–1.02)	0.821
WBC	1.01(0.96–1.07)	0.594	1.024(0.98–1.08)	0.339
N%	0.97(0.93–1.00)	0.061	0.96(0.92–1.00)	0.037

CIRP = cold-inducible RNA-binding protein, APACHE II = Acute Physiology and Chronic Health Evaluation II, SOFA = Sepsis-related Organ Failure Assessment, PCT = procalcitonin, WBC = white blood cell, N% = neutrophil ratio.

CIRP0.1 = CIRP level/10.

HR = hazard ratio.

A p-value < 0.05 was considered to be statistically significant.

^c = 0.998–1.002