Figure 7. Central role of intestinal Mfs in generation of commensal-induced Th17 cells.
Intestinal Mfs acquire antigens from epithelium-associated SFB and initiate SFB-specific Th17 cell responses. CD103+ DCs are dispensable for the induction of Th17 cells. Intestinal Mfs may participate in the Th17 cell differentiation stage locally in the LP or collaborate with CX3CR1+ DCs for antigen transfer into MLN or Th17 cell priming/maintenance in the LP.