Table 4.
Means, standard deviations and 95% confidence intervals of biomarkers in participants with IC/BPS only and those with additional comorbid conditions (Fibromyalgia, Irritable Bowel Syndrome, vulvodynia, Chronic Fatigue Syndrome, Temperomandibular Disorder)
| Variable Mean (S.D.) 95% CI Inflammatory Variables | IC Only n=26 | IC Comorbid n=40 | p |
|---|---|---|---|
| TLR-4 inflammatory response | −.36 (1.13) −.82, .09 |
.24 (.85) −.03, .51 |
.016 |
| IL-1β + LPS | 3.11 (.93) 2.73,3.48 |
3.58 (.44) 3.44, 3.72 |
.008 |
| IL-6 + LPS | 4.15 (.40) 3.99, 4.31 |
4.28 (.42) 4.14, 4.41 |
.205 |
| TLR-2 inflammatory response | −.10 (1.06) −.53, .32 |
.07 (.97) −.24, .38 |
.501 |
| IL-1β + SAC | 1.17 (1.19) .69, 1.65 |
1.44 (1.14) 1.08, 1.81 |
.365 |
| IL-6 + SAC | 1.68 (1.37) 1.13, 2.24 |
1.79 (1.22) 1.40, 2.19 |
.719 |
| Cortisol Slope (ln transformed) |
n=22 −.11 (.06) −.14, −.08 |
n=34 −.11 (.07) −.13, −.08 |
.955 |
| IL-6 plasma (log10 transformed) | .33 (.35) −.75, 0.84 |
.46 (.26) .00, .97 |
.097 |
| Duration of Symptoms (years) | 6.91 (7.48) 3.89, 9.93 |
8.3 (8.00) 5.71, 10.90 |
.48 |
IL-6=Interleukin-6. IL-1β=Interleukin-1 beta. LPS= lipopolysaccharide. SAC= Staphylococcus aureus Cowan. TLR = Toll-Like Receptor.