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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Aug 6;25(19):4225–4231. doi: 10.1016/j.bmcl.2015.07.105

Table 1.

In vitro antibacterial activity of 2-(3′-indolyl)-N-arylthiazole-4-carboxamides 17a–p

graphic file with name nihms-713879-t0008.jpg ZOI (mm) and MIC (μg/mL) values
Compound Gram-positive bacteria Gram-negative bacteria
S. auresus B. cereus E. coli P. putida
R1 R2 R3 ZOI MIC ZOI MIC ZOI MIC ZOI MIC
17a H H C6H5 14 50 - - 13 100 13 100
17b H H 4-CH3C6H4 - - - - 12 100 12 100
17c H H 4-CH3OC6H4 11 100 12 100 14 50 12 100
17d H H 3,4-(CH3O)2C6H3 14 50 14 50 16 25 16 25
17e H H 3,4,5-(CH3O)3C6H2 12 100 14 50 14 50 13 100
17f H H 4-FC6H4 12 100 10 100 13 100 12 100
17g H H 4-(CH3)2NC6H4 13 100 14 50 12 100 14 50
17h H H CH2C6H5 - - - - 13 100 13 100
17i OCH3 H 3,4,5-(CH3O)3C6H2 13 100 14 50 18 12.5 18 12.5
17j Br H 4-CH3OC6H4 14 50 15 50 15 12.5 16 12.5
17k Br H 3,4,5-(CH3O)3C6H2 15 50 16 12.5 14 50 16 12.5
17l F H 4-CH3OC6H4 12 100 13 100 14 50 13 100
17m F H 3,4,5-(CH3O)3C6H2 12 100 10 100 14 50 14 50
17n H 4-ClC6H4CH2 C6H5 12 100 13 100 15 50 15 50
17o H 4-ClC6H4CH2 4-CH3OC6H4 14 100 15 50 16 12.5 16 12.5
17p H 4-ClC6H4CH2 3,4,5-(CH3O)3C6H2 13 100 12 100 15 50 14 100
Ciprofloxacin 23 6.25 24 6.25 23 6.25 21 12.5

The zone of inhibition and MIC values for compounds with significant activity are shown in bold