Table 2.
In vitro cytotoxicity (with FBS) of 2-(3′-indolyl)-N-arylthiazole-4-carboxamides 17a-p
|
IC50(μM)a,b | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Compd | R1 | R2 | R3 | HEK 293T | C4-2 | HeLa | PC3 | MDA- MB-231 |
LNCaP |
| 17a | H | H | C6H5 | >100 | >100 | >100 | >100 | >100 | >100 |
| 17b | H | H | 4-CH3C6H4 | >100 | >100 | >100 | >100 | >100 | >100 |
| 17h | H | H | CH2C6H5 | 74.50±1.19 | >100 | 41.38±2.03 | >100 | >100 | >100 |
| 17i | OCH3 | H | 3,4,5-(CH3O)3C6H2 | 8.74±1.26 | >100 | 9.98±0.01 | >100 | >100 | 84.80±1.21 |
| 17k | Br | H | 3,4,5-(CH3O)3C6H2 | 32.82±0.75 | >100 | 93.03±3.96 | >100 | >100 | >100 |
| 17l | F | H | 4-CH3OC6H4 | >100 | >100 | 33.48±0.98 | >100 | >100 | 75.42±1.88 |
| 17m | F | H | 3,4,5-(CH3O)3C6H2 | 66.02±3.28 | >100 | 48.85±1.35 | >100 | >100 | 88.51±3.25 |
| 17n | H | 4-ClC6H4CH2 | C6H5 | >100 | >100 | 32.07±0.87 | >100 | >100 | 68.94±2.49 |
| 17o | H | 4-ClC6H4CH2 | 4-CH3OC6H4 | >100 | >100 | 90.85±3.73 | >100 | >100 | >100 |
| 17p | H | 4-ClC6H4CH2 | 3,4,5-(CH3O)3C6H2 | >100 | >100 | >100 | >100 | >100 | >100 |
| Doxorubicin | 0.75±0.03 | 0.57±0.08 | 0.43±0.10 | 9.8±0.40 | 6.29±0.24 | 7.40±1.10 | |||
a
IC50 values are the mean of three different experiments performed in duplicate;
b
17c-g and 17j: ND