It is estimated that 3–12% of the US population is affected by NASH. 5 Although NASH patients have a higher risk of progression, it should be noted that some patients may progress directly from NAFL to advanced fibrosis. 12, 13 Approximately 2–3% of patients with NASH cirrhosis will develop HCC each year.26 Some NASH patients without cirrhosis may develop HCC, but the magnitude of risk is not clear.27, 28
sHCC = hepatocellular carcinoma; NAFL = nonalcoholic fatty liver; NAFLD = nonalcoholic fatty liver disease; NASH = nonalcoholic steatohepatitis; US = United States