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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Inflamm Bowel Dis. 2015 Oct;21(10):2393–2402. doi: 10.1097/MIB.0000000000000499

Fig. 3. AMP peptide reduces colonic shortening in T-cell transfer model of IBD.

Fig. 3

RAG-1−/− mice were reconstituted with splenic CD45RBhigh CD4+ T cells (4 X 105 cells, 95% pure). Treatment with AMP peptide (25 mg peptide/kg, s.c.) or vehicle began when the animals lost 5% body weight, or exhibited diarrhea or hematochezia. Whole colons were harvested and lengths were measured on days 10 or 21 (n=20; * P=0.032, ** P=0.00005).