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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Neurobiol Dis. 2015 Mar 11;81:66–75. doi: 10.1016/j.nbd.2015.02.026

Fig. 5.

Fig. 5

Both Irp1 and Irp2 bind to the HIF2α IRE. Band-shift experiments were done with MEF cells to measure the HIF2α IRE and ferritin IRE binding activities of Irp1 and Irp2 following a published method (Ghosh et al., 2008). HIF2α is highly expressed in brain endothelial cells (Tian et al., 1997).