Fig. 15.

Trial-related information processed is layer specific and modulated by cortical loop afferents. The figure shows the average percentage of information above chance decoded by single neurons in each layer. Trial information could be decoded from all S1 layers significantly above chance (open bars). The largest amount of information decoded was from neurons recorded from the infragranular layers. Additionally, inactivation of M1 (shaded) or S1 (solid) differentially affected the amount of information decoded from each layer. M1 inactivation reduced the amount of trial-related information decoded in all layers, and this effect was more pronounced in layer IV. S1 inactivation contralateral to the recording site reduced the amount of trial-related information only in supragranular layers. *P <0.05, ***P < 0.001.