FIG 9.
The virulence of the wild type was compared to that of O-Ag capsule-deficient (ΔyihO and ΔyshA-yihU) strains in a murine model of systemic infection. BALB/c mice were orally inoculated with 1.6 × 106 CFU (±3.2 × 105 CFU) of either wild-type S. Typhimurium or the ΔyihO or ΔyshA-yihW mutant, The animals were monitored for health daily and were euthanized when moribund. The survival curves were analyzed using a log-rank (Mantel-Cox) test and were found not to reach statistical significance (P = 0.093).