FIG 4.
Changes in community diversity and structure over time during relapse of CDI and FMT. (A) Community diversity of the microbiota in mice with CDI relapse (inverse Simpson index, y axis). Points represent individual samples, and lines represent the mean diversity per group. (B) Mean distance between the community structure on sampling day and conventional/untreated over time in mice without or with FMT, calculated using the Yue and Clayton dissimilarity metric (θYC). (C) Mean θYC distance between the community structure of mice with or without FMT over time. Error bars represent upper and lower quartiles. A pairwise Wilcoxon rank sum test was used to calculate significance between mice with or without FMT (*, P < 0.05; **, P < 0.005; ***, P < 0.0005).