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Proinflammatory mediator expression in TLR4−/− eyes infected with B. cereus. C57BL/6J and TLR4−/− mouse eyes were infected with 100 CFU B. cereus. Concentrations of TNF-α, IL-6, IL-1β, and KC were quantified by an ELISA. Overall, higher levels of TNF-α, KC, IL-6, and IL-1β were synthesized in infected eyes of C57BL/6J mice than in infected eyes of TLR4−/− mice. Values represent means ± SEM for ≥5 eyes per time point with at least two independent experiments. *, P ≤ 0.036.
