Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 10;83(10):4165–4173. doi: 10.1128/IAI.00814-15

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Kulohoma et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.

PMC Copyright notice

FIG 1 — Meningitis- and bacteremia-associated pneumococcal core genomes based on 140 invasive isolates. (A) Box and whisker plot of the number of core gene orthologous clusters observed as the subset of isolates included in the analysis increases, where the subset ranged from 1 to the total number of isolates (n = 140). To generate a subset of isolates, n isolates are randomly selected from the data set. The core genome size is then calculated for n isolates. Each random subset of a given size is generated 100 times. (B) Box and whisker plot of the number of meningitis and bacteremia core gene orthologous clusters observed as the number of isolates included in the analysis increases, where the subset ranged from 1 to the total number of isolates (n = 70). To generate a subset of isolates, n isolates are randomly selected from the data set. The core genome size is then calculated for n isolates. Each random subset of a given size is generated 100 times. (C) Map of the proportion of meningitis-specific core genes in the bacteremia-associated pneumococcal data set (genes present and absent are represented in gray and white, respectively). A list of meningitis-specific proteins is on the x axis, and individual bacteremia-specific isolates with a phylogenetic tree are on the y axis. (D) Map of the proportion of bacteremia-specific genes in the meningitis-associated pneumococcal data set (genes present and absent are represented in gray and white, respectively). A list of bacteremia-specific proteins is on the x axis, and individual meningitis isolates with a phylogenetic tree are on the y axis.

FIG 1 — Meningitis- and bacteremia-associated pneumococcal core genomes based on 140 invasive isolates. (A) Box and whisker plot of the number of core gene orthologous clusters observed as the subset of isolates included in the analysis increases, where the subset ranged from 1 to the total number of isolates (n = 140). To generate a subset of isolates, n isolates are randomly selected from the data set. The core genome size is then calculated for n isolates. Each random subset of a given size is generated 100 times. (B) Box and whisker plot of the number of meningitis and bacteremia core gene orthologous clusters observed as the number of isolates included in the analysis increases, where the subset ranged from 1 to the total number of isolates (n = 70). To generate a subset of isolates, n isolates are randomly selected from the data set. The core genome size is then calculated for n isolates. Each random subset of a given size is generated 100 times. (C) Map of the proportion of meningitis-specific core genes in the bacteremia-associated pneumococcal data set (genes present and absent are represented in gray and white, respectively). A list of meningitis-specific proteins is on the x axis, and individual bacteremia-specific isolates with a phylogenetic tree are on the y axis. (D) Map of the proportion of bacteremia-specific genes in the meningitis-associated pneumococcal data set (genes present and absent are represented in gray and white, respectively). A list of bacteremia-specific proteins is on the x axis, and individual meningitis isolates with a phylogenetic tree are on the y axis.