Fig 1.

Current standard-of-care treatment strategy for high-risk neuroblastoma. Therapy consists of three treatment blocks: induction (chemotherapy and primary tumor resection); consolidation (high-dose chemotherapy with autologous stem-cell rescue and external-beam radiotherapy [XRT]); and postconsolidation (anti–ganglioside 2 immunotherapy with cytokines and cis-retinoic acid). ch, chimeric; CHO, Chinese hamster ovary; GM-CSF, granulocyte macrophage colony-stimulating factor; IL-2, interleukin-2; IV, intravenous; mAB, monoclonal antibody.