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. 2015 Sep 11;7(1):97. doi: 10.1186/s13148-015-0131-z

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© Qin et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Baseline gene expression and DNA methylation in YB5 cells. a. Percent DNA methylation at CpG sites within ±500 bp from TSS of 9083 genes (x-axis) vs gene expression at baseline (y-axis). b. Baseline methylation vs expression for the subset of regulated genes showing expression changes ≥1.5-fold after treatment with decitabine, carboplatin, or their combination. The broken line divides the data into four quadrants: (Q1) upper left, unmethylated expressed genes; (Q2) upper right, methylated expressed genes; (Q3) lower left, unmethylated silenced genes; and (Q4) lower right, methylated silenced genes