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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Invest Dermatol. 2015 Apr 30;135(10):2377–2384. doi: 10.1038/jid.2015.167

Figure 4. MMP-10 regulates collagenase activity of tissue macrophages.

Figure 4

Wildtype (WT) and Mmp10−/− skin explants were cultured in the upper chambers of a 24-transwell plate containing (a) PBS or clodronate liposomes (n = 3/genotype) or (b) the apoptosis-inducing peptide M2pepKLA or ScrM2peptideKLA (20 µg/ml; n=5/genotype). FITC-conjugated type I collagen was added to the medium in the lower chamber, and collagenase activity was measured 72 h later. ** p <0.01.