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. Author manuscript; available in PMC: 2016 Nov 19.
Published in final edited form as: Neuroscience. 2015 Mar 12;309:51–67. doi: 10.1016/j.neuroscience.2015.03.006

Figure 6.

Figure 6

(A) Choline acetyltransferase (ChAT) activity increased in the hippocampus in MCI and returned to control levels in mild AD. (Band C) Schematic drawings of coronal section of the hippocampus illustrating the loss of innervation to the hippocampus arising from the glutamatergic layer II entorhinal cortex neurons (red) triggering a cholinergic plasticity response (blue) which likely originates from the septal cholinergic projection neurons into the denervated glutamatergic sites in the hippocampus in MCI. Abbreviations: AD: Alzheimer’s disease; CA1, CA2, CA3, CA4- Cornu Ammonis hippocampal subfields; CS- collateral sulcus, DG- dentate gyrus, Ent- entorhinal cortex; f- fornix, gl- granular cell layer of the hippocampus, ml- molecular layer of the hippocampus; NCI- no cognitive impairment, MCI-mild cognitive impairment, pp-perforant pathway, TEC- transentorhinal cortex, Sub-subiculum