TABLE 1.

Example of 1 Proposed Patient Selection Protocol for TPIAT⁶⁹

Patient must fulfill criteria 1–5 given in the following text.

1. Diagnosis of chronic pancreatitis, based on chronic abdominal pain of >6-mo duration with at least 1 of the following:

Pancreatic calcifications on CT scan.

At least 2 of the following: ≥4/9 criteria on EUS, compatible ductal or parenchymal abnormalities on secretin MCRP; abnormal endoscopic pancreatic function tests (peak Hco2 ≤80 mM).

Histopathology confirmed diagnosis of chronic pancreatitis.

Compatible clinical history and documented hereditary pancreatitis (PRSS1 gene mutation).

Or

History of recurrent acute pancreatitis (more than 1 episodes of characteristic pain associated with imaging diagnostic of acute pancreatitis and/or elevated serum amylase or lipase >3 times upper limit of normal).

2. At least 1 of the following:

Daily narcotic dependence.

Pain resulting in impaired quality of life, which may include: inability to attend school, recurrent hospitalizations, or inability to participate in usual, age-appropriate activities.

3. Complete evaluation with no reversible cause of pancreatitis present or untreated.

4. Failure to respond to maximal medical and endoscopic therapy.

5. Adequate islet cell function (nondiabetic or C-peptide positive)

Patients with C-peptide negative diabetes meeting criteria 1–4 are candidates for TP alone.

Adapted with permission from Bellin et al. Adaptations are themselves works protected by copyright. So in order to publish this adaptation, authorization must be obtained from both the owner of the copyright in the original work and the owner of copyright in the translation or adaptation.

CT indicates computed tomography; EUS, endoscopic ultrasound; MRCP, Magnetic Resonance Cholangiopancreatography.