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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Neurotoxicol Teratol. 2015 Mar 13;49:31–40. doi: 10.1016/j.ntt.2015.03.001

Figure 1. Diffusion of carbon monoxide (CO) into tissue is dictated by the Haldane equation (Bissonnette, 1977a; Jain, 2009).

Figure 1

Following formation of carboxyhemoglobin (COHb), CO diffuses from the capillaries into the tissue compartments. Tissue tension of CO (pCO) is determined by COHb concentration, partial pressure of oxygen (pO2), the affinity of hemoglobin for CO (M), and the concentration of oxyhemoglobin (O2Hb). The Haldane equation also dictates transplacental CO diffusion.