Figure 2. Example of release data and empirical fit.

The cumulative release profile for reservoir devices is linear after an initial burst release (A, Diltiazem). Data fit is based on the equation M = A*Dk*Cs^DP*t / L and the combined parameter Dk is determined empirically. Release in the matrix system (B, Metoprolol) is described as fraction released and is fit with two equations $[\raisebox{1ex}{$M$}\!\left/ \!\raisebox{-1ex}{$M_T$}\right.=({(\mathit{D}*\mathit{Y}\prime )}^{\frac{1}{2}}*A*{((2C_A-{C_S}^{API}){C_S}^{API})}^{\frac{1}{2}}*t^{\frac{1}{2}})/f_d*m;\raisebox{1ex}{$M$}\!\left/ \!\raisebox{-1ex}{$M_T$}\right.<\mathbf{0.6}][\raisebox{1ex}{$M$}\!\left/ \!\raisebox{-1ex}{$M_T$}\right.=1-\raisebox{1ex}{$8$}\!\left/ \!\raisebox{-1ex}{${\pi }^2$}\right.\text{exp}[\raisebox{1ex}{$-{\pi }^2\mathit{D}\mathit{t}$}\!\left/ \!\raisebox{-1ex}{$L^2$}\right.];\raisebox{1ex}{$M$}\!\left/ \!\raisebox{-1ex}{$M_T$}\right.>0.6]$ and two empirical parameters (D’, Y’). Data sets are from a single release experiment and fits are based on average empirical parameters from full data set (n=2–5).