Table I.
Physical properties and sources of Pharmaceuticals
| API | Form | Supplier/Catalog# | MW API15 |
MW DP15 |
Cs API (mg/L)15, 21–25 |
Cs DP (mg/L)15,21–25 |
LogP15 | pKa15 |
|---|---|---|---|---|---|---|---|---|
| Caffeine | Caffeine | Sigma/C0705 | 194 | 194 | 16005 | 16005 | −0.07 | 10.4 |
| Diltiazem | Diltiazem HCl | Sigma/D2521 | 415 | 451 | 464 | 50000 | 2.8 | 8.2 |
| Diclofenac | Diclofenac Na | Sigma/D6899 | 296 | 318 | 17.8 | 1771 | 4.51 | 4.15 |
| Famotidine | Famotidine | Sigma/F6889 | 337 | 337 | 999 | 999 | −0.64 | 8.38 |
| Hydrocortisone | Hydrocortisone | Sigma/H0888 | 363 | 363 | 319 | 319 | 1.61 | 12.58 |
| Labetalol | Labetalol HCl | Sigma/L1011 | 328 | 364 | 117 | 10100 | 3.09 | 8.05 |
| Ranitidine | Ranitidine HCl | Fluka/P500026 | 314 | 350 | 24700 | 1800 | 0.27 | 8.08 |
| Verapamil | Verapamil HCl | Sigma/V4629 | 455 | 491 | 4 | 45500 | 3.9 | 8.92 |
| Ibuprofen | Ibuprofen | Sigma/I4883 | 206 | 206 | 470 | 470 | 3.5 | 4.91 |
| Atenolol | Atenolol | Sigma/A7655 | 266 | 266 | 13300 | 13300 | 0.16 | 9.6 |
| Metoprolol | MetoprololTartrate | VWR/AAJ61920-06 | 267 | 685 | 16900 | 1.88 | 9.67 | |
| Aspirin | Aspirin | Sigma/A5376 | 180 | 180 | 4608 | 4608 | 1.19 | 3.49 |