Table II.
Summary of PCL Matrix Samples Analyzed
| Pharmaceutical | n | % Loading (w/w API/PCL) |
Membrane Thickness (µm) |
D‘ (mm2/hr) | Y' |
|---|---|---|---|---|---|
| Aspirin | 3 | 3 | 15.8 | 1.3E-05 | 1.38E-10 |
| 3 | 4 | 17.3 | 2.4E-05 | 8.44E-11 | |
| 3 | 5 | 19.5 | 1.4E-05 | 6.67E-11 | |
| 3 | 5 | 17.4 | 1.8E-05 | 1.65E-10 | |
| 3 | 6 | 20.2 | 2.2E-05 | 1.96E-10 | |
| Atenolol | 3 | 4 | 12 | 1.5E-05 | 5.93E-11 |
| 3 | 5 | 10.4 | 1.0E-05 | 7.49E-11 | |
| 3 | 7 | 19.5 | 7.8E-06 | 9.88E-11 | |
| 3 | 7 | 7.7 | 1.0E-05 | 6.52E-11 | |
| Caffeine | 3 | 2 | 8.6 | 8.2E-06 | * |
| 3 | 3 | 10.2 | 7.9E-06 | * | |
| 3 | 4 | 10.4 | 1.7E-05 | * | |
| 3 | 5 | 19.5 | 1.3E-05 | 1.84E-11 | |
| 3 | 7 | 13.2 | 2.3E-05 | 1.75E-11 | |
| Diclofenac-Na | 3 | 4 | 19.5 | 5.3E-06 | 1.16E-07 |
| Ibuprofen | 3 | 3 | 16.2 | 1.0E-05 | 1.99E-08 |
| 3 | 4 | 14.7 | 1.4E-05 | 1.82E-08 | |
| 3 | 5 | 19.8 | 1.0E-05 | 2.87E-08 | |
| Labetalol-HCl | 3 | 5 | 19.5 | 3.4E-06 | 3.41E-09 |
| Metoprolol Tartrate | 3 | 16 | 20.3 | 3.0E-06 | 1.82E-10 |
| Ranitidine-HCl | 3 | 9 | 19.5 | 2.6E-06 | 1.54E-10 |
| Verapamil-HCl | 3 | 4 | 13.7 | 1.2E-06 | 6.29E-08 |
| 3 | 6 | 14.5 | 1.1E-06 | 1.01E-07 | |
| 3 | 11 | 13.6 | 1.2E-06 | 5.52E-07 | |
| 3 | 12 | 19.2 | 4.8E-06 | 2.04E-07 |
*
Y’ not calculated for these samples. Drug loading was below Cs and data is fit with equation 1b only.