Table 3. Multivariable Analysis Comparing outcomes between HLA 8/8 to HLA 7/8 Donors.
| Variable | RR | 95% CI Lower Limit | 95% CI Upper Limit | p value | |
|---|---|---|---|---|---|
| aGVHD II-IV | |||||
| 8/8 allele match | 1 | 0.003 | |||
| 7/8 allele match | 1.29 | 1.09 | 1.53 | ||
| aGVHD III-IV | |||||
| 8/8 allele match | 1 | 0.05 | |||
| 7/8 allele match | 1.69 | 1.00 | 3.36 | ||
| CGVHD | |||||
| 8/8 allele match | 1 | 0.15 | |||
| 7/8 allele match | 1.11 | 0.96 | 1.28 | ||
| TRM | |||||
| 8/8 allele match | 1 | <.0001 | |||
| 7/8 allele match | 1.52 | 1.29 | 1.79 | ||
| Relapse | |||||
| 8/8 allele match | 1 | 0.92 | |||
| 7/8 allele match | 1.007 | 0.87 | 1.17 | ||
| DFS | |||||
| 8/8 allele match | 1 | 0.0015 | |||
| 7/8 allele match | 1.20 | 1.07 | 1.34 | ||
| OS | |||||
| 8/8 allele match | 1 | 0.0001 | |||
| 7/8 allele match | 1.25 | 1.12 | 1.40 | ||
Multivariable mo dels also included the following c ovariates: aGV HD II-IV: G VHD prophylaxis, graft type, in vivo T cell depletion, DPB1 matching; aGVHD III-IV: GVHD prophylaxis, TBI, in vivo T cell depletion; cGVHD: year of transplant, in vivo T cell depletion; TRM: graft type, recipient age, Karnofsky performance score, disease, GVHD prophylaxis; Relapse: Karnofsky performance score, disease status, conditioning intensity, in vivo T cell depletion; DFS: Karnofsky performance score, disease status, conditioning intensity; OS: graft type, recipient age, Karnofsky performance score, donor age, and disease status.