Table 2.
Characteristics of First-Time NMDP Donors Who Donated PBSC Between January 1, 2004 and July 31, 2009 by Collection Center Sizea
| Variable | 0-204 collections N (%) |
205-520 collections N (%) |
521-1135 collections N (%) |
1136-5953 collections N (%) |
Unknown N(%) |
p-value |
|---|---|---|---|---|---|---|
| Number of donors | 543 | 1674 | 2845 | 1686 | 20 | |
| Number of centers | 22 | 24 | 24 | 22 | 6 | |
| Median household income in the donor's census block group, 2012b,c |
<0.001 | |||||
| 0-25,000 | 27 (5) | 37 (2) | 75 (4) | 43 (3) | 0 | |
| 25,001-50,000 | 184 (34) | 475 (30) | 512 (30) | 473 (31) | 4 (57) | |
| 50,001-100,000 | 251 (47) | 813 (51) | 827 (49) | 713 (46) | 2 (29) | |
| >100,000 | 56 (10) | 205 (13) | 252 (15) | 276 (18) | 0 | |
| Unknown | 19 (4) | 55 (3) | 34 (2) | 32 (2) | 1 (14) | |
| Donor race | <0.001 | |||||
| Non-Hispanic white | 458 (84) | 1168 (70) | 2183 (77) | 1258 (75) | 16 (80) | |
| Hispanic, all races | 26 (5) | 202 (12) | 241 (8) | 139 (8) | 1 (5) | |
| Non-Hispanic black | 13 (2) | 72 (4) | 148 (5) | 87 (5) | 0 | |
| Non-Hispanic Asian/non-Hispanic Pacific Islander |
17 (3) | 117 (7) | 58 (2) | 102 (6) | 0 | |
| Non-Hispanic other, unknown |
29 (5) | 115 (7) | 215 (8) | 100 (6) | 3 (15) | |
| Donor-related | ||||||
| Donor age at donation | <0.001 | |||||
| 18 to 29 | 141 (26) | 509 (30) | 995 (35) | 521 (31) | 7 (35) | |
| 30 to 39 | 185 (34) | 531 (32) | 935 (33) | 550 (33) | 6 (30) | |
| 40 to 49 | 158 (29) | 431 (26) | 672 (24) | 430 (26) | 3 (15) | |
| 50+ | 59 (11) | 203 (12) | 243 (9) | 185 (11) | 4 (20) | |
| Median (Range) | 37 (19-60) | 36 (18-60) | 35 (19-61) | 36 (19-61) | 35 (20-61) | <0.001 |
| Donor sex | <0.001 | |||||
| Female | 230 (42) | 746 (45) | 908 (32) | 706 (42) | 8 (40) | |
| Male | 313 (58) | 928 (55) | 1937 (68) | 980 (58) | 12 (60) | |
| Donor BMI (kg/m2) | 0.085 | |||||
| Underweight (<18.5) | 2 (<1) | 9 (1) | 17 (1) | 13 (1) | 0 | |
| Normal (18.5-24.9) | 146 (27) | 504 (30) | 795 (28) | 521 (31) | 4 (20) | |
| Overweight (25-29.9) | 202 (37) | 641 (38) | 1183 (42) | 625 (37) | 8 (40) | |
| Obese (30+) | 193 (36) | 520 (31) | 849 (30) | 527 (31) | 8 (40) | |
| Unknown | 0 N/A | 0N/A | 1N/A | 0N/A | 0N/A | |
| Median (Range) | 28.0 (18.0-49.7) | 27.4 (16.2-49.1) | 27.4 (16.7-51.8) | 27.4 (16.9-56.2) | 27.7 (19.5-39.6) | 0.082 |
| Baseline WBC (×109/L) | ||||||
| N Eval | 543 | 1674 | 2845 | 1686 | 20 | |
| Median (Range) | 6.4 (3.2-14.0) | 6.3 (2.9-15.6) | 6.3 (2.4-16.0) | 6.4 (2.3-14.5) | 6.6 (4.5-11.0) | 0.683 |
| Baseline platelets (×109/L) | ||||||
| N Eval | 543 | 1673 | 2844 | 1686 | 20 | |
| Median (Range) | 252 (122-474) | 257 (127-474) | 251 (100-548) | 257 (112-494) | 242 (170-397) | 0.002 |
| Baseline hemoglobin (g/dL) | ||||||
| N Eval | 543 | 1674 | 2845 | 1686 | 20 | |
| Median (Range) | 14.7 (10.5-17.9) | 14.5 (9.6-18.3) | 14.9 (9.4-18.6) | 14.6 (9.6-19.0) | 14.6 (12.5-16.5) | <0.001 |
| Baseline neutrophils (×109/L) |
||||||
| N Eval | 543 | 1673 | 2844 | 1686 | 20 | |
| Median (Range) | 4.1 (1.3-10.9) | 3.9 (1.2-12.9) | 3.9 (1.0-12.8) | 4.0 (1.3-11.8) | 3.8 (2.4-6.1) | 0.152 |
| Baseline mononuclear cells (×109/L) |
||||||
| N Eval | 538 | 1672 | 2836 | 1681 | 20 | |
| Median (Range) | 2.3 (1.1-4.9) | 2.3 (0.7-7.3) | 2.3 (0.8-5.9) | 2.3 (0.3-5.0) | 2.5 (1.4-5.0) | 0.100 |
| Donor CMV | <0.001 | |||||
| Unknown/Inconclusive | 0 | 4 (<1) | 3 (<1) | 3 (<1) | 0 | |
| Negative | 329 (61) | 937 (56) | 1790 (63) | 1046 (62) | 15 (75) | |
| Positive | 214 (39) | 733 (44) | 1052 (37) | 637 (38) | 5 (25) | |
| Year of donation | <0.001 | |||||
| 2004 | 107 (20) | 169 (10) | 356 (13) | 176 (10) | 6 (30) | |
| 2005 | 111 (20) | 258 (15) | 426 (15) | 303 (18) | 4 (20) | |
| 2006 | 90 (17) | 294 (18) | 504 (18) | 299 (18) | 1 (5) | |
| 2007 | 79 (15) | 331 (20) | 574 (20) | 307 (18) | 6 (30) | |
| 2008 | 88 (16) | 393 (23) | 648 (23) | 367 (22) | 1 (5) | |
| 2009 | 68 (13) | 229 (14) | 337 (12) | 234 (14) | 2 (10) | |
| Two-day collection | <0.001 | |||||
| No | 290 (53) | 1288 (77) | 2293 (81) | 1058 (63) | 15 (75) | |
| Yes | 253 (47) | 386 (23) | 552 (19) | 628 (37) | 5 (25) | |
| Pre-collection WBC (×109/L) | ||||||
| N Eval | 543 | 1674 | 2845 | 1685 | 20 | |
| Median (Range) | 37.5 (9.6-98.9) | 38.3 (11.3-93.4) | 38.9 (11.2-117) | 38.9 (10.6-89.7) | 37.6 (18.9-64.3) | 0.431 |
| CD34+ at collection (×106) | ||||||
| N Eval | 409 | 1508 | 2430 | 1480 | 18 | |
| Median (Range) | 636.0 (7.1-3486.2) | 611.4 (0.9-4013.6) | 743.6 (2.8-5967.0) | 657.2 (0.7-13428.1) | 592.2 (77.8-1262.7) | <0.001 |
| Day 1 G-CSF dose per donor weight (μg/kg) |
||||||
| N Eval | 543 | 1674 | 2836 | 1685 | 20 | |
| Median (Range) | 10.5 (5.3-14.6) | 10.6 (7.1-14.5) | 10.6 (2.5-15.7) | 10.6 (4.5-17.7) | 10.5 (9.0-12.8) | 0.021 |
| Total G-CSF dose per donor weight (μg/kg) |
||||||
| N Eval | 543 | 1674 | 2842 | 1686 | 20 | |
| Median (Range) | 52.3 (35.0-73.2) | 52.9 (31.2-70.6) | 52.7 (5.2-74.4) | 52.7 (21.2-71.4) | 52.3 (35.9-63.9) | <0.001 |
a
Apheresis center size based on reaccreditation numbers; uses total number of autologous, related and unrelated allogeneic PBSC collections for calendar years 2004-2008.
b
Donors from the centers who provided only non-residential zip codes (e.g. work, university or donor center zip codes) were excluded from the SES analyses.
c
If the census block group could not be located from reported street address, median household income from donor’s zip code was used instead.
Abbreviations: NMDP – National Marrow Donor Program; PBSC – peripheral blood stem cell; BMI – body mass index; WBC – white blood cells; CMV – Cytomegalovirus.