Pathways of steroid hormone synthesis in 21-hydroxylase deficiency. HSD3B2, 3β-hydroxysteroid dehydrogenase type 2; CYP17A1, 17α-hydroxylase/17,20-lyase; CYB5A, cytochrome b5; CYP11B1, 11β-hydroxylase; CYP11B2, aldosterone synthase; DOC, 11-deoxycorticosterone; DHT, dehydrotestosterone; AKR1C3, 17β-hydroxysteroid dehydrogenase type 5; AKR1C2,4, aldo-keto reductase types 1C2 and 1C4; HSD17B6, 17β-hydroxysteroid dehydrogenase type 6 (an oxidative 3α-HSD); SRD5A1 and SRD5A2, 5α-reductase, types 1 and / 2, respectively.