Table 1.

Brief summary of activity-dependent changes in microtubule stability in neuronal cells

Microtubule dynamics
Targets	System	Findings	References
Tyrosinated tubulin	Primary neuron	Tyrosinated tubulin extended into dendritic protrusions. Potassium chloride treatment increases microtubule invasions of dendritic protrusions.	(Hu et al., 2008)
Tubulin EB3	Primary neuron	Microtubule invasions of dendritic protrusions. BDNF-induced increase of spine number is blocked by microtubule destabilizer (nocodazole) treatment.	(Gu et al., 2008)
EB3	Primary neuron	Microtubule invasions of dendritic protrusions.	(Jaworski et al., 2009)
Tubulin	Hippoca mpal slices	Electron microscopic analysis shows that there is redistribution of microtubules in dendritic spines following LTP induction.	(Mitsuyama et al., 2008)
Acetylated tubulin	Hippoca mpal slices	Potassium chloride or NMDA treatment enhances the level of acetylated tubulin.	(Pandey and Sharma, 2011)
Tyrosinated tubulin	Mouse dentate gyrus (contextu al fear condition ing)	Tyrosinated tubulin increases 0.5-1 h and decreases 8 h following context-shock exposure. Increased tyrosinated tubulin is observed in mice received context only or immediate shock.	(Uchida et al., 2014)
Detyrosinate d tubulin	Mouse dentate gyrus (contextu al fear condition ing)	Detyrosinated tubulin decreases 0.5-1 h and increases 8 h following context-shock exposure. Decreased detyrosinated tubulin is observed in mice received context only or immediate shock.	(Uchida et al., 2014)
Microtubule s	Mouse hippoca mpus (contextu al fear condition ing)	Microtubule stabilizer (paclitaxel) injection immediately after contextual fear conditioning reduces long-term memory. Paclitaxel and microtubule destabilizer (nocodazole) injection 8 h after contextual fear conditioning enhances or reduces long-term memory, respectively.	(Uchida et al., 2014)
Microtubule s	Mouse hippoca mpus (contextu al fear condition ing)	Microtubule turnover is changed following contextual fear conditioning. Nocodazole injection reduces contextual fear memory and spine number.	(Fanara et al., 2010)
Microtubule s	Mouse (Y maze)	Microtubule stabilizer (epothilone D) treatment rescues deficits in axonal microtubule density and spatial learning observed in aged PS19 mice.	(Zhang et al., 2012)
Microtubule s	Mouse (Morris water maze)	Paclitaxel treatment leads to reduced microtubule dynamics and deficits in spatial learning.	(Atarod et al., 2015)

Please note that this is not an exclusive survey and that the findings listed here do not cover all the contents of the reference papers.