Table 2.
Characteristics of patients with multiple myeloma who received and did not receive prophylactic levofloxacin during neutropenia after autologous hematopoietic stem cell transplantation (HSCT).1,2
| Characteristics | No levofloxacin prophylaxis (n = 127) |
Levofloxacin prophylaxis (n = 148) |
P |
|---|---|---|---|
| Demographics | |||
| Age (years) | 56 (49–61) | 59 (53–64) | 0.009 |
| Female sex | 56 (44) | 74 (50) | 0.33 |
| Myeloma characteristics | |||
| Immunoglobulin type | 0.12 | ||
| IgG | 66 (52) | 93 (63) | |
| IgA | 27 (21) | 22 (15) | |
| None (light chain) | 34 (27) | 31 (21) | |
| Other | 0 (0) | 2 (1) | |
| Light chain type | |||
| Kappa | 80 (63) | 85 (57) | 0.35 |
| Lambda | 47 (37) | 63 (43) | |
| Years since diagnosis | 1 (1–3) | 1 (1–2) | 0.72 |
| Previous HSCT | 23 (18) | 16 (11) | 0.08 |
| Comorbidities | |||
| Charlson comorbidity index score | 2 (2–3) | 2 (2–3) | 0.37 |
| Myocardial infarction | 13 (10) | 5 (3) | 0.02 |
| Congestive heart failure | 4 (3) | 1 (1) | 0.19 |
| Cerebrovascular disease | 3 (2) | 3 (2) | 1.00 |
| COPD | 1 (1) | 2 (1) | 1.00 |
| Connective tissue disease | 1 (1) | 5 (3) | 0.22 |
| Liver disease | 1 (1) | 5 (3) | 0.22 |
| Diabetes | 16 (13) | 13 (9) | 0.31 |
| Kidney disease | 13 (10) | 8 (5) | 0.13 |
| Solid tumor | 6 (5) | 10 (7) | 0.47 |
| Baseline serum creatinine (mg/dL) | 0.9 (0.7–1.3) | 0.8 (0.7–1.1) | 0.19 |
| Baseline serum albumin (mg/dL) | 3.6 (3.3–4.0) | 3.2 (2.9–3.5) | <0.001 |
| Clostridium difficile infection within 90 days prior to HSCT |
1 (1) | 1 (1) | 1.00 |
| Transplant characteristics | |||
| Conditioning regimen | 0.02 | ||
| Melphalan (200 mg/m2) | 112 (88) | 112 (76) | |
| Melphalan (dose < 200 mg/m2) | 8 (6) | 24 (16) | |
| Melphalan + (bendamustine or carmustine) |
7 (6) | 12 (8) | |
| Central venous catheter (CVC) type | 0.30 | ||
| PICC line | 29 (23) | 42 (28) | |
| Tunneled CVC | 98 (77) | 106 (72) | |
| # of CD34 cells infused (x106/kg) | 6.5 (4.7–9.2) | 5.1 (4.1–7.2) | <0.001 |
| Duration of neutropenia, days | 7 (6–9) | 7 (6–8) | 0.03 |
All categorical variables are expressed as No. (%) of total. All continuous variables are expressed as median (interquartile range). COPD, chronic obstructive pulmonary disease; PICC, peripherally inserted central catheter.
1
Eight patients in Period 2 did not receive levofloxacin prophylaxis because of allergy or intolerance.
2
This table analyzes 275 transplants performed among 263 unique patients.