Table 3. Genetic Association of PER3 SNPs and Depressive Symptoms GDS ≥2.
Associations between directly genotyped Per3 SNPs and geriatric depression scale (GDS) score ≥2 are shown. Odds ratios (OR) and 95% confidence intervals (CI) are given for having depressive symptoms compared with the GDS 0-2 group. MAF is the weighted average between MAFs for the SOF and MrOS cohorts. The p-values for associations passing multiple testing criteria for significance (p-value <0.00017) are bolded and underlined. Nominally significant p-values (≥0.00017 but ≤0.05) are underlined. Non-significant p-values > 0.05 are in normal font; MAF: Minor allele frequency; SOF: Study of Osteoporotic Fractures; MrOS Osteoporotic Fractures in Men Study.
| Directly Genotyped SNPs | Combined Subthreshold/Depressed (GDS≥2) | |||||||
|---|---|---|---|---|---|---|---|---|
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| SNP | Location | Alleles | MAF | Mode | MrOS (n=605) | SOF (n=691) | Meta (n=1296) | |
| rs12137927 | Intron | C/T | 0.224 | Add | OD (95%CI) | 0.89 (0.76-1.04) | 0.75 (0.63-0.89) | 0.83 (0.73-0.93) |
| Test statistic (df) | −1.45( 1df ) | −3.26( 1df ) | 3.27 | |||||
| P-value | 0.1478 | 0.001119 | 0.001075 | |||||
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| Dom | OD (95%CI) | 0.84 (0.70-1.018) | 0.67 (0.54-0.82) | 0.75 (0.66-0.87) | ||||
| Test statistic (df) | −1.78( 1df ) | −3.88( 1df ) | 3.95 | |||||
| P-value | 0.07564 | 0.000104 | 0.00007769 | |||||
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| Rec | OD (95%CI) | 1.01 (0.67-1.51) | 0.99 (0.62-1.57) | 1.001 (0.73-1.36) | ||||
| Test statistic (df) | 0.03( 1df ) | −0.05( 1df ) | 0.01 | |||||
| P-value | 0.9747 | 0.962 | 0.9949 | |||||
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| 2DF | Test statistic (df) | −1.19(2df ) | −2.39( 1df ) | 0.67 | ||||
| P-value | 0.769 | 0.4903 | 0.5043 | |||||
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| rs228644 | Intron | G/A | 0.412 | Add | OD (95%CI) | 0.84 (0.74-0.96) | 0.99 (0.86-1.143) | 0.91 (0.83-1.00) |
| Test statistic (df) | −2.49( 1df ) | −0.11( 1df ) | 1.91 | |||||
| P-value | 0.01266 | 0.909 | 0.056 | |||||
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| Dom | OD (95%CI) | 0.76 (0.63-0.93) | 0.90 (0.73-1.10) | 0.82(0.72-0.95) | ||||
| Test statistic (df) | −2.71( 1df ) | −1.04( 1df ) | 2.69 | |||||
| P-value | 0.00683 | 0.2998 | 0.007235 | |||||
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| Rec | OD (95%CI) | 0.86(0.67-1.10) | 1.16(0.89-1.50) | 0.99(0.83-1.18) | ||||
| Test statistic (df) | −1.22( 1df ) | 1.1( 1df ) | 0.15 | |||||
| P-value | 0.2229 | 0.2694 | 0.8782 | |||||
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| 2DF | Test statistic (df) | −1.05(2df ) | −1.84(2df ) | 1.86 | ||||
| P-value | 0.03261 | 0.7345 | 0.0632 | |||||
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| rs228682 | Intron | T/C | 0.412 | Add | OD (95%CI) | 0.85(0.74-0.97) | 0.99(0.86-1.15) | 0.91(0.83-1.007) |
| Test statistic (df) | −2.41( 1df ) | −0.09( 1df ) | 1.83 | |||||
| P-value | 0.01583 | 0.9323 | 0.068 | |||||
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| Dom | OD (95%CI) | 0.77 (0.63-0.93) | 0.90(0.73-1.10) | 0.83(0.72-0.95) | ||||
| Test statistic (df) | −2.71( 1df ) | −1.02( 1df ) | 2.68 | |||||
| P-value | 0.00683 | 0.3059 | 0.007425 | |||||
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| Rec | OD (95%CI) | 0.87(0.68-1.12) | 1.164(0.90-1.51) | 0.99(0.83-1.20) | ||||
| Test statistic (df) | −1.08( 1df ) | 1.14( 1df ) | 0.09 | |||||
| P-value | 0.2821 | 0.2532 | 0.93 | |||||
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| 2DF | Test statistic (df) | −1.19(2df ) | −1.86(2df ) | 1.80 | ||||
| P-value | 0.04204 | 0.7087 | 0.07187 | |||||
Test statistic: Wald test for SOF and MrOs analyses; Z-statistic based approach weighted by the square root of the sample size for meta-analysis