Table 2.
Pre-operative and post-operative findings in three study groups
| Data variables | Intra-prime furosemide (Group A) (n = 42) | Intermittent furosemide therapy (Group B) (n = 42) | Control (Group C) (n = 42) | P for ANOVA |
|---|---|---|---|---|
| Pre-operative blood urea nitrogen | 19.4 ± 3.02 | 19.2 ± 3.3 | 19.6 ± 2.9 | 0.311 |
| Post-operative blood urea nitrogen | 16.1 ± 1.00 | 25.7 ± 3.3* | 15.8 ± 1.2 | 0.002 |
| 1st day post-operative blood urea nitrogen | 18.9 ± 1.35 | 19.9 ± 1.5 | 18.1 ± 1.1 | 0.271 |
| 2nd day post-operative blood urea nitrogen | 20.1 ± 1.50 | 28.3 ± 3.6* | 19.3 ± 1.4 | 0.001 |
| Pre-operative creatinine | 1.5 ± 0.40 | 1.4 ± 0.4 | 1.7 ± 0.5 | 0.132 |
| Post-operative creatinine | 1.2 ± 0.10 | 1.3 ± 0.1 | 1.2 ± 0.1 | 0.320 |
| 1st day post-operative creatinine | 1.2 ± 0.10 | 1.4 ± 0.1 | 1.3 ± 0.1 | 0.211 |
| 2nd day post-operative creatinine | 1.2 ± 0.10 | 1.5 ± 0.1 | 1.2 ± 0.1 | 0.103 |
| Pre-operative hemoglobin | 14.5 ± 1.20 | 14.9 ± 1.4 | 14.3 ± 1.3 | 0.111 |
| Post-operative hemoglobin | 10.3 ± 1.30 | 9.8 ± 1.2 | 9.9 ± 1.2 | 0.101 |
| 1st day post-operative hemoglobin | 9.1 ± 1.10 | 9.4 ± 1.2 | 9.1 ± 1.1 | 0.171 |
| 2nd day post-operative hemoglobin | 9.3 ± 1.20 | 9.7 ± 1.1 | 9.7 ± 1.3 | 0.262 |
| Pre-operative sodium | 142.0 ± 1.50 | 140.0 ± 1.6 | 140.0 ± 1.6 | 0.251 |
| Post-operative sodium | 136.0 ± 1.40 | 148.0 ± 3.2* | 139.0 ± 1.1 | 0.004 |
| 1st day post-operative sodium | 140.0 ± 1.00 | 148.0 ± 0.8* | 141.0 ± 1.0 | 0.002 |
| 2nd day post-operative sodium | 142.0 ± 1.90 | 148.0 ± 1.4* | 139.0 ± 1.0 | 0.001 |
| Pre-operative lactate level | 1.9 ± 1.150 | 2.0 ± 1.1 | 2.1 ± 1.2 | 0.320 |
| Intra-operative lactate | 4.0 ± 1.40 | 3.9 ± 0.3 | 3.8 ± 0.8 | 0.162 |
| Pre-operative fluid balance | 1333.0 ± 405.00 | 1379.0 ± 392.0 | 1411.0 ± 417.0 | 0.120 |
| Postoperative fluid balance | 1908.0 ± 381.00 | 2514.0 ± 662.0* | 1717.0 ± 295.0 | 0.003 |
| Post-operative fluid balance in first day of ICU | 2798.0 ± 194.00 | 2849.0 ± 171.0 | 2717.0 ± 150.0 | 0.114 |
| Post-operative fluid balance in second day of ICU | 1935.0 ± 169.00 | 2573.0 ± 205.0* | 1574.0 ± 155.0 | 0.005 |
| Intra-operative urine output | 543.0 ± 280.00 | 583.0 ± 246.0 | 550.0 ± 296.0 | 0.211 |
| Post-operative urine output | 298.0 ± 23.00 | 280.0 ± 29.0 | 298.0 ± 27.0 | 0.130 |
| Preoperative glomerular filtration rate | 71.5 ± 4.30 | 58.0 ± 3.8 | 63.0 ± 3.9 | 0.120 |
| Post-operative glomerular filtration rate | 70.6 ± 3.70 | 59.5 ± 4.1 | 65.6 ± 3.9 | 0.121 |
| Preoperative potassium | 4.2 ± 1.00 | 4.1 ± 1.0 | 4.1 ± 1.0 | 0.222 |
| Postoperative potassium | 4.4 ± 1.00 | 4.2 ± 1.0 | 4.3 ± 1.0 | 0.271 |
| First day post op potassium | 4.2 ± 1.00 | 4.4 ± 1.0 | 4.2 ± 1.0 | 0.232 |
| Second day post-operative potassium | 4.2 ± 1.00 | 4.4 ± 1.0 | 4.2 ± 1.0 | 0.221 |
Data are presented as mean ± SD; There was no difference within the two other groups, one-way ANOVA test was used for data analysis;
*
The results of this test demonstrated that the group indicated by asterix (*) differed significantly from the two other groups (P < 0.050);
SD: Standard deviation; ICU: Intensive care unit