Table 3.

Associations between computational model parameters for the verbal task and different gene sets

Model parameter	Database	Gene set (number of genes in gene set)	Discovery sample (n = 1,239)		Replication sample (n = 526)
			Pnominal	PFDR	Pnominal
Learning rate α	Reactome	Amine compound SLC transporters (27)	2.0 × 10−4	0.0405	0.0031
Decision threshold β	KEGG	Axon guidance (129)	4.4 × 10−5	0.0067	0.405
Repetition-based memory improvement c	Reactome	L1CAM interactions (86)	3.0 × 10−6	0.0011	0.0231
		Interaction between L1 and ankyrins (23)	1.0 × 10−3	0.0365	0.176
Modulation by negative emotional arousal εneg	Reactome	Collagen formation (58)	1.0 × 10−4	0.0129	0.0025
	Gene Ontology	Transmembrane receptor protein tyrosine kinase activity (43)	4.1 × 10−5	0.0124	0.0212
		Transmembrane receptor protein kinase activity (51)	1.0 × 10−4	0.0398	0.059

Only the gene sets surviving MAGENTA FDR correction in the discovery sample are shown. The replicated gene sets are shown in bold. Interaction between L1 and ankyrins is a subset of L1CAM interactions, and transmembrane receptor protein tyrosine kinase activity is a subset of transmembrane receptor protein kinase activity. L1CAM interactions contains four genes [EGFR, FGFR1, and neuropilin 1 and 2 (NRP1, and NRP2)] shared with transmembrane receptor protein tyrosine kinase activity.